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CGRP, Migraine, and Brain MRI in CADASIL: A Pilot Study
Eric D Goldstein1, Neethu Gopal2, Mohammed K Badi2
1Department of Neurology, The Warren Alpert Medical School of Brown University, Providence, RI.
The Neurologist
|February 2, 2023
Summary
Migraine may slow microangiopathy in CADASIL, independent of disability severity. Calcitonin gene-related peptide (CGRP) levels did not differ between groups, suggesting it may not be key in CADASIL migraine. Further research is needed.
Area of Science:
- Neurology
- Neuroimaging
- Vascular Neurology
Background:
- Migraine is linked to neuroimaging changes in CADASIL.
- The impact of migraine-related disability (MRD) and CGRP on these changes is unclear.
Purpose of the Study:
- To investigate if MRD or interictal serum CGRP levels correlate with neuroimaging findings in CADASIL patients.
- To explore potential radiographic implications of migraine in CADASIL.
Main Methods:
- Cross-sectional analysis of CADASIL patients with and without migraine.
- Assessment of neuroimaging (MRI) and MRD using validated scales.
- Measurement of interictal serum CGRP levels.
Main Results:
- Migraine patients were younger and showed fewer cerebral microbleeds and anterior temporal lobe T2 hyperintensities.
- No significant radiographic associations were found with MRD.
- Interictal serum CGRP levels did not differ between migraine and non-migraine groups.
Conclusions:
- Migraine might offer a protective effect against microangiopathy in CADASIL, potentially independent of MRD.
- CGRP levels do not appear to be a significant factor in migraine pathophysiology within this CADASIL cohort.
- Larger studies are required to confirm findings and address age differences.
