Related Experiment Video
Updated: Aug 12, 2025
04:00
Author Spotlight: Establishing a Practical and Cost-Effective Protocol for Corneal Sensitivity Testing in Clinical Settings
Published on: August 2, 2024
2.1K
Novel Treatments for Chronic Ocular Surface Pain
Simran Mangwani-Mordani1,2, Courtney F Goodman2, Anat Galor1,2
1Surgical Services, Miami Veterans Affairs Medical Center, Miami, FL; and.
Cornea
|February 2, 2023
Summary
Ocular surface pain can stem from nociceptive or neuropathic causes. When pain persists, addressing neuropathic mechanisms with various agents is crucial for effective patient management.
Area of Science:
- Ophthalmology
- Pain Medicine
- Neuroscience
Background:
- Ocular surface pain is a complex condition with multiple potential causes.
- Identifying the specific pain mechanisms is essential for effective treatment.
Purpose of the Study:
- To outline the different etiologies of ocular surface pain.
- To guide clinicians in identifying and managing neuropathic pain components.
Main Methods:
- Review of current literature on ocular surface pain mechanisms.
- Clinical observation and diagnostic criteria for differentiating pain types.
Main Results:
- Ocular surface pain involves nociceptive, peripheral neuropathic, and central neuropathic mechanisms.
- Clinical assessment can reveal underlying contributors to persistent ocular pain.
Conclusions:
- Neuropathic mechanisms are key considerations for persistent ocular surface pain.
- A multimodal treatment approach including oral, topical, and adjuvant therapies is recommended for neuropathic ocular pain.
Related Concept Videos
01:27Open Angle Glaucoma: Treatment
516
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
516
01:28Angle Closure Glaucoma: Treatment
604
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
604
01:23Local Anesthetics: Common Agents and Their Applications
507
Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
507
01:22Drug Delivery: Miscellaneous Routes
429
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
429