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Allogeneic Solid Platelet-Rich Plasma for Persistent Epithelial Neurotrophic Defects: A Protocol and Pilot Study.

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  • 1Department of Medical and Surgical Specialties, Radiological Specialties and Public Health, University of Brescia, ASST Spedali Civili, Brescia, Italy; and.

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Summary
This summary is machine-generated.

Allogeneic solid platelet-rich plasma (PRP) effectively healed persistent epithelial defects in a pilot study. This treatment shows promise for neurotrophic corneal wounds, reducing symptoms and improving ocular surface health.

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Area of Science:

  • Ophthalmology
  • Regenerative Medicine
  • Biomaterials

Background:

  • Persistent neurotrophic epithelial defects are challenging ocular surface conditions unresponsive to conventional treatments.
  • Platelet-rich plasma (PRP) is a concentrate of platelets and growth factors with potential regenerative properties.

Purpose of the Study:

  • To describe the procedure for obtaining allogeneic solid platelet-rich plasma (PRP).
  • To evaluate the efficacy of allogeneic solid PRP in a pilot study for patients with persistent neurotrophic epithelial defects.

Main Methods:

  • Four patients with persistent neurotrophic epithelial defects received allogeneic solid PRP activated with thrombin and calcium gluconate.
  • PRP was applied to the cornea using fibrin glue and a soft contact lens.
  • Outcomes including healing time, visual acuity, and ocular surface parameters were assessed over a 4-month follow-up.

Main Results:

  • Complete healing of persistent epithelial defects occurred within 10 days for all patients.
  • Significant reductions in Ocular Surface Disease Index (OSDI) scores and Oxford staining scores were observed.
  • No recurrences of epithelial defects were noted during the follow-up period.

Conclusions:

  • Allogeneic solid PRP, combined with fibrin glue, appears to be a promising therapeutic option for promoting wound healing in neurotrophic persistent epithelial defects.
  • Further prospective studies are warranted to confirm the efficacy and optimal use of this treatment.