Related Experiment Video
Updated: Aug 12, 2025
Author Spotlight: Advancing Research in Corneal Opacity Treatment and Regeneration
Published on: August 4, 2023
Paraproteinemic Keratopathy in a Patient With Previous LASIK Procedure Mimicking Lattice Corneal Dystrophy
Jesus Guerrero-Becerril1, Itamar Vigderovich-Cielak1, Yvette Neme-Yunes2
1Instituto de Oftalmología Fundación Conde de Valenciana FAP, Cornea, External Diseases and Refractive Surgery, Mexico City, Mexico.
Purpose:
The aim of this study was to report a unique clinical presentation of paraproteinemic keratopathy after a myopic uneventful laser in situ keratomileusis (LASIK) procedure that led to the diagnosis of gammopathy of undetermined significance.
Methods:
This was an interventional case report. A 55-year-old woman present with bilateral branching opacities limited to the optical zone of myopic LASIK. The patient's medical history was unremarkable.
Results:
After ruling out a mutation in TGF-β1 , a systemic workup was performed, revealing an IgG level of 12.8 mg/dL, lambda-free light chain of 12.8 mg/dL, and M-spike of 0.6 g/dL. Bone marrow aspiration was slightly hypercellular, without evidence of neoplastic infiltration by plasma cells. The patient underwent 3 cycles of systemic chemotherapy, with improvement in best-corrected visual acuity.
Conclusions:
Paraproteinemic keratopathy is a rare clinical presentation that may lead to a systemic diagnosis of hematologic malignancy. To the best of our knowledge, this is the first reported case of paraproteinemic keratopathy after LASIK.
