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Updated: Aug 12, 2025

Calorespirometry: A Powerful, Noninvasive Approach to Investigate Cellular Energy Metabolism
Published on: May 31, 2018
Indirect calorimetry: should it be part of routine care or only used in specific situations?
Martin Sundström Rehal1,2, Oana A Tatucu-Babet3, Timo Oosterveld2
1Department of Perioperative Medicine and Intensive Care, Karolinska University Hospital.
Purpose Of Review:
Indirect calorimetry (IC) is increasingly recommended to guide energy delivery in the ICU. This review aims to provide a critical overview of current literature in support of these recommendations.
Recent Findings:
There is insufficient evidence to ascertain a mortality benefit from IC-guided energy delivery. However, large variations in energy expenditure during critical illness pose a risk for significant under- and overfeeding if IC is not routinely used.
Summary:
Even in the absence of demonstrable clinical benefits, there is a strong physiological rationale in favor of performing IC. Measurements can be prioritized in complex patients and should be repeated during prolonged ICU stay.
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