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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
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The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Related Experiment Video

Updated: Aug 12, 2025

Microfluidics in Assessing Platelet Function
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Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

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Alternative blood products in trauma.

Kathryn M Jan1, Shweta Mohapatra, Tiffany S Moon

  • 1Department of Anesthesiology & Pain Management, UT Southwestern Medical Center, Dallas, Texas, USA.

Current Opinion in Anaesthesiology
|February 2, 2023
PubMed
Summary

Trauma patients with bleeding complications can benefit from alternative blood products. Tranexamic acid and prothrombin complex concentrate are established options, with ongoing research into further alternatives for hemorrhage control.

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Area of Science:

  • Trauma and Emergency Medicine
  • Hematology
  • Pharmacology

Background:

  • Hemorrhage and coagulopathy significantly increase mortality in trauma patients.
  • Blood products are essential for resuscitation but are limited in availability.
  • This review explores alternatives to traditional blood products in trauma care.

Approach:

  • Comprehensive literature review of alternative blood products for trauma.
  • Analysis of current research and established clinical practices.
  • Examination of emerging therapies and their supporting evidence.

Key Points:

  • No single alternative fully replaces traditional blood products.
  • Tranexamic acid and prothrombin complex concentrate are widely adopted.
  • Research continues to develop novel hemostatic agents and supportive therapies.

Conclusions:

  • Hemorrhage control and resuscitation are paramount in trauma-induced coagulopathy.
  • Alternative products like tranexamic acid and prothrombin complex concentrate are valuable adjuncts.
  • Viscoelastic assays guide treatment, while iron, EPO, and vitamin D address long-term recovery.