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Related Experiment Video

Updated: Aug 12, 2025

Insertion, Maintenance, and Removal of the Percutaneous Dual Lumen Cannula Right Ventricular Assist Device
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Clinical Validation of a Neointima-Inducing Inflow Cannula in a Continuous Flow Left Ventricular Assist Device.

Yukiko Yamada1, Noriko Kikuchi2, Saeko Yoshizawa3

  • 1From the Department of Cardiovascular Surgery Tokyo Women's Medical University, Tokyo, Japan.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|February 2, 2023
PubMed
Summary

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A novel titanium mesh-wrapped inflow cannula for left ventricular assist devices (LVADs) prevents wedge thrombus formation in long-term use. While not reducing overall neurological events, it promotes neointimal growth, improving device performance.

Area of Science:

  • Cardiovascular Surgery
  • Biomedical Engineering
  • Medical Device Innovation

Background:

  • Wedge thrombus formation at the inflow cannula of continuous left ventricular assist devices (LVADs) is a significant cause of systemic thromboemboli.
  • A titanium mesh-wrapped inflow cannula (GU30) was developed to potentially overcome limitations of standard smooth surface cannulae (GU10).

Purpose of the Study:

  • To clinically validate the efficacy of the titanium mesh-wrapped inflow cannula (GU30) compared to the standard cannula (GU10) in LVAD patients.
  • To assess the impact of the GU30 cannula on survival, thromboembolism, and bleeding events.

Main Methods:

  • Retrospective cohort analysis of patients implanted with EVAHEART LVAD, comparing GU10 and GU30 cannulae.
  • Comparison of clinical outcomes including survival, thromboembolism incidence, and bleeding events.

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  • Gross and histopathological analysis of explanted GU30 cannulae.

    • Main Results:

    • No significant differences in survival, severe emboli, or cerebral bleeding were observed during initial LVAD implantation.
    • Severe emboli occurred earlier with the GU30 cannula compared to GU10.
    • In long-term LVAD support, neointima fully covered the GU30 inflow, preventing wedge thrombus formation.
    • The GU30 cannula did not significantly reduce the overall incidence of neurological events.

    Conclusions:

    • The titanium mesh-wrapped inflow cannula (GU30) effectively induces autologous neointimal growth.
    • This neointimal coverage prevents wedge thrombus formation in late-phase LVAD implantation.
    • While not significantly reducing overall neurological events, the GU30 shows promise for long-term LVAD performance by mitigating thrombus formation.