Creatine kinase is associated with glycated haemoglobin in a nondiabetic population. The Tromsø study
1Department of Clinical Medicine, UiT - The Arctic University of Norway, Tromsø, Norway.
Insights
Creatine kinase (CK) is linked to higher glycated haemoglobin (HbA1C) levels in non-diabetic individuals. This study found CK independently predicts HbA1C, suggesting its role in metabolic health monitoring.
Area of Science:
- Biochemistry
- Metabolic Health
- Cardiovascular Risk Assessment
Background:
- Creatine kinase (CK) is associated with insulin resistance and cardiovascular disease risk factors like hypertension and obesity.
- Previous research highlights CK's connection to metabolic and cardiovascular health markers.
Purpose of the Study:
- To investigate whether creatine kinase (CK) predicts glycated haemoglobin (HbA1C) levels.
- To assess the relationship between CK and HbA1C in a general non-diabetic population.
Main Methods:
- Analysis of data from 11,662 non-diabetic participants in the Tromsø study (Tromsø 6).
- Variance and multivariate analyses were used to examine associations between CK and HbA1C (%).
- Participants were defined as non-diabetic with HbA1C <6.5%.
Main Results:
- Elevated CK was found in 4.66% of participants.
- Mean HbA1C was significantly higher in the high CK group (5.62%) compared to the normal CK group (5.52%).
- CK showed a significant independent association with HbA1C, with a 1-unit increase in log CK correlating to a 0.17-unit increase in HbA1C.
Conclusions:
- A positive and independent association exists between creatine kinase (CK) and glycated haemoglobin (HbA1C).
- CK may serve as a predictive marker for elevated HbA1C in the general non-diabetic population.
- These findings contribute to understanding CK's role in metabolic health and cardiovascular risk.
Background:
Creatine kinase (CK) has been associated with insulin resistance and identified as a risk marker of cardiovascular disease largely by its relationship with hypertension and increased body mass index. This study determined whether CK is a predictor of glycated haemoglobin (HbA1C) in a nondiabetic general population.
Methods:
Associations between CK and the outcome variable HbA1C (%) were performed by variance and multivariate analyses in 11662 nondiabetic subjects defined as HbA1C (%) <6.5 who participated in the population based Tromsø study (Tromsø 6) in Norway.
Results:
Abnormal elevated CK was detected in 543/11662 participants (4.66%). Mean HbA1C (%) in the "high CK" group was 5.62 (SD = 0.33) compared to 5.52 (SD = 0.36) in the "normal CK" group, P <0.001. CK increased significantly and linearly with higher levels of HbA1C (%) quartiles in women (P <0.001) and non-linearly in men (P <0.001). In a multivariate analysis, CK was independently associated with HbA1C (%) after adjusting for age, sex, body mass index, blood pressure, glucose, lipids, C-reactive protein, creatinine, alanine transaminase and aspartate aminotransferase. A 1-unit increase in log CK was associated with a 0.17-unit increase in HbA1C (%).
Conclusion:
These data demonstrate a positive and independent association between CK and glycated haemoglobin in a nondiabetic general population.
