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Related Experiment Video

Updated: Aug 12, 2025

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

Endothelial dysfunction in ME/CFS patients.

Miriam Kristine Sandvik¹, Kari Sørland², Elisabeth Leirgul³

¹Department of Psychiatry and Addiction, Telemark Hospital Trust, Skien, Norway.

|February 2, 2023

Summary

This summary is machine-generated.

Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) exhibit impaired large and small blood vessel function. This suggests vascular homeostasis may contribute to ME/CFS symptoms.

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Last Updated: Aug 12, 2025

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

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Published on: October 22, 2014

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Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test

Published on: April 27, 2016

Area of Science:

Cardiovascular Research
Neurology
Immunology

Background:

Previous research suggests endothelial dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).
Understanding vascular contributions to ME/CFS is crucial for developing effective treatments.

Purpose of the Study:

To investigate large-vessel and small-vessel endothelial function in ME/CFS patients.
To compare endothelial function between ME/CFS patients and healthy controls.
To explore the relationship between endothelial function and clinical outcomes in ME/CFS.

Main Methods:

A substudy of the RituxME trial, a randomized, double-blind, placebo-controlled phase III study.
Measured flow-mediated dilation (FMD) for large-vessel function and post-occlusive reactive hyperemia (PORH) for small-vessel function.
Assessed 39 ME/CFS patients and compared them to healthy controls at baseline and after 18 months of treatment.

Main Results:

ME/CFS patients showed significantly reduced FMD (5.1% vs. 8.2%) and PORH (1354 PU vs. 2208 PU) compared to controls.
No significant differences in symptom changes or vascular measures between rituximab and placebo groups.
A slight improvement in clinical symptoms and PORH was observed in ME/CFS patients as a group after 18 months.

Conclusions:

ME/CFS patients exhibit impaired macro- and microvascular endothelial function.
Vascular homeostasis appears to play a role in the clinical presentation of ME/CFS.
Further research into vascular mechanisms is warranted for ME/CFS management.