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Feedback Inhibition

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Related Experiment Video

Updated: Aug 12, 2025

Measurement of Neurophysiological Signals of Ignoring and Attending Processes in Attention Control

Measurement of Neurophysiological Signals of Ignoring and Attending Processes in Attention Control

Published on: July 5, 2015

Suppressing feedback signals to visual cortex abolishes attentional modulation.

Samantha R Debes¹, Valentin Dragoi^1,2

¹Department of Neurobiology and Anatomy, McGovern Medical School, University of Texas at Houston, Houston, TX 77030, USA.

Science (New York, N.Y.)

|February 2, 2023

Summary

This summary is machine-generated.

Top-down attention signals from V4 to V1 enhance visual perception. Inactivating these feedback connections impairs neural responses and accuracy, proving feedback

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Last Updated: Aug 12, 2025

Measurement of Neurophysiological Signals of Ignoring and Attending Processes in Attention Control

Measurement of Neurophysiological Signals of Ignoring and Attending Processes in Attention Control

Published on: July 5, 2015

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention

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Published on: September 11, 2017

Investigating the Deployment of Visual Attention Before Accurate and Averaging Saccades via Eye Tracking and Assessment of Visual Sensitivity

Investigating the Deployment of Visual Attention Before Accurate and Averaging Saccades via Eye Tracking and Assessment of Visual Sensitivity

Published on: March 18, 2019

Area of Science:

Neuroscience
Visual Perception
Cognitive Neuroscience

Background:

Attention enhances sensory perception by improving neural encoding.
Cortical feedback projections are hypothesized to carry top-down attention signals.
Causal evidence for feedback's role in attention has been lacking.

Purpose of the Study:

To causally test the hypothesis that cortical feedback projections mediate attention's effects on visual coding.
To investigate the role of feedback from V4 to V1 in visual attention.

Main Methods:

Used viral tools to trace and selectively inactivate feedback projections from V4 to V1 in monkeys.
Monkeys performed a visual-spatial attention task during neural recordings.
Analyzed the impact of feedback inactivation on single-cell responses and neural population accuracy in V1 and V4.

Main Results:

Inactivating V4 feedback terminals in V1 reduced neuronal response gain and impaired population encoding accuracy.
These effects were layer-dependent, primarily in superficial V1 layers.
The observed effects propagated to the downstream area V4.

Conclusions:

Cortical feedback, specifically from V4 to V1, causally enhances visual sensory coding during attention.
Attention modulates visual processing through layer-specific alterations in corticocortical feedback strength.
This provides direct evidence for the role of top-down feedback in attention-mediated perception.