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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
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Updated: Aug 12, 2025

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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Bone involvement in primary cutaneous diffuse large B-cell lymphoma, leg-type.

Claire Laurent1, Caroline Ram-Wolff2,3, Saskia Ingen-Housz-Oro3,4

  • 1Department of Dermatology, University Hospital of Rennes, Rennes, France.

Clinical and Experimental Dermatology
|February 2, 2023
PubMed
Summary
This summary is machine-generated.

Primary cutaneous diffuse large B-cell lymphoma, leg-type with bone involvement indicates a poor prognosis. Early detection using advanced imaging like PET scans is crucial for better outcomes in these aggressive lymphoma cases.

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Area of Science:

  • Oncology
  • Dermatology
  • Hematology

Background:

  • Primary cutaneous diffuse large B-cell lymphoma, leg-type (PCDLBCL-LT) is an aggressive malignancy.
  • Bone involvement in PCDLBCL-LT is uncommon and not well-documented.

Purpose of the Study:

  • To describe bone localization in PCDLBCL-LT.
  • To evaluate the impact of bone involvement on prognosis and treatment efficacy.

Main Methods:

  • Retrospective case series of five patients with PCDLBCL-LT and bone involvement.
  • Diagnostic imaging included positron emission tomography (PET) and computed tomography (CT) scans.
  • Treatment regimens involved rituximab (RTX) and polychemotherapy (PCT).

Main Results:

  • Bone involvement was diagnosed at initial staging in four patients and post-fracture in one.
  • Asymptomatic bone lesions distant from skin sites were observed.
  • All patients receiving first-line RTX-PCT experienced early relapses or progression.
  • Second-line treatments demonstrated limited efficacy.

Conclusions:

  • Bone involvement in PCDLBCL-LT is associated with a poor prognosis.
  • Standard CT scans may miss asymptomatic bone lesions.
  • Systematic advanced imaging (e.g., PET) is recommended for baseline staging and follow-up.