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Updated: Aug 12, 2025

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lncRNA GAS5 and RUNX1 Genes in Children With Primary Immune Thrombocytopenia

Hossam Hodeib1, Doaa El Amrousy2, Eman Elaskary2

  • 1Clinical Pathology Department, Faculty of Medicine.

Journal of Pediatric Hematology/Oncology
|February 2, 2023
PubMed

Insights

Growth arrest specific 5 (GAS5) and runt-related transcription factor 1 (RUNX1) gene expression levels can predict the disease course in children with immune thrombocytopenia (ITP). These genes may serve as valuable prognostic markers for ITP recovery and chronicity.

Area of Science:

  • Pediatric Hematology
  • Molecular Biology
  • Genetics

Background:

  • Immune thrombocytopenia (ITP) is an autoimmune disorder affecting platelet counts.
  • Identifying reliable biomarkers for predicting ITP prognosis in children is crucial for effective management.
  • Growth arrest specific 5 (GAS5) and runt-related transcription factor 1 (RUNX1) are genes with potential roles in immune regulation.

Purpose of the Study:

  • To evaluate the expression levels of GAS5 and RUNX1 in children newly diagnosed with ITP.
  • To determine the prognostic value of GAS5 and RUNX1 expression in predicting ITP recovery and chronicity in pediatric patients.

Main Methods:

  • A prospective cohort study involving 100 children with newly diagnosed ITP and 100 healthy controls.
  • Gene expression levels of GAS5 and RUNX1 were measured at diagnosis before treatment initiation.
  • Statistical analysis was performed to correlate gene expression levels with ITP disease course.

Main Results:

  • GAS5 was significantly under-expressed, while RUNX1 was over-expressed in children with ITP compared to controls.
  • Specific expression levels of GAS5 and RUNX1 were associated with faster recovery from ITP.
  • Optimal cut-off values for GAS5 and RUNX1 were identified to predict complete recovery and chronic ITP with high sensitivity.

Conclusions:

  • GAS5 and RUNX1 gene expression levels show potential as predictive biomarkers for ITP outcomes in children.
  • These genes may assist in stratifying pediatric ITP patients for tailored treatment strategies.
  • Further research is warranted to validate GAS5 and RUNX1 as clinical prognostic markers for childhood ITP.

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