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Tailoring crystallinity for hemocompatible and durable PEEK cardiovascular implants.

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Enhancing polyetheretherketone (PEEK) crystallinity improves hemocompatibility by reducing platelet adhesion and hemolysis. This simple method optimizes PEEK for cardiovascular devices.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Cardiovascular Engineering

Background:

  • Polymers offer advantages over traditional heart valve materials.
  • Polyetheretherketone (PEEK) shows promise but faces hemocompatibility challenges.
  • Current hemocompatibility solutions for PEEK are often complex.

Purpose of the Study:

  • To investigate the impact of polymer crystallinity on PEEK hemocompatibility.
  • To evaluate amorphous, semi-crystalline, and crystalline PEEK, plus a carbon fiber composite (CFPEEK).
  • To determine if crystallinity can be a simple method to enhance PEEK performance.

Main Methods:

  • Synthesized and characterized amorphous, semi-crystalline, and crystalline PEEK samples.
  • Investigated a highly crystalline carbon fiber (CF)/PEEK composite (CFPEEK).
  • Assessed functional group density, platelet adhesion, hemolysis, and thrombin generation.

Main Results:

  • Higher PEEK crystallinity correlated with increased surface carbonyl groups.
  • Increased crystallinity significantly reduced platelet adhesion, hemolysis, and thrombin generation.
  • CFPEEK demonstrated excellent hemocompatibility and mechanical properties.

Conclusions:

  • Tailoring PEEK crystallinity is an effective strategy to improve hemocompatibility.
  • Crystallinity control offers a simple method to enhance both hemocompatibility and mechanical properties.
  • CFPEEK's properties support its use in novel cardiovascular device designs.