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Published on: December 28, 2014
Surface-based morphometry study of brain in patients with carbon monoxide poisoning
Tianhong Wang1, Yanli Zhang2, Jiang Nan2
1Deparment of Radiology, The First Hospital of Lanzhou University. The Intelligent Imaging Medical Engineering Research Center of Gansu Province, Accurate Image Collaborative Innovation International Science and Technology Cooperation Base of Gansu Province, Radiological Clinical Medicine Research Center of Gansu Province, Lanzhou, Gansu, China; Department of Neurology, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
Carbon monoxide poisoning (COP) causes cortical thinning, especially in fronto-parietal regions. This thinning, particularly in the right superior frontal gyrus and rostral middle frontal gyrus, correlates with cognitive deficits in patients.
Area of Science:
- Neuroimaging
- Neurology
- Toxicology
Background:
- Carbon monoxide poisoning (COP) is known to cause neurological damage.
- Delayed neurological sequelae (DNS) are a common complication following COP.
- Previous studies focused on volume abnormalities, but cortical thickness and shape changes remain less understood.
Purpose of the Study:
- To investigate cortical thickness and shape differences in COP patients compared to healthy controls.
- To compare cortical changes between COP patients with and without delayed neurological sequelae (DNS).
- To explore the relationship between cortical damage and neurological deficits.
Main Methods:
- Surface-based morphometry was employed to analyze brain structure.
- Cortical thickness and shape indices were compared between COP patients (n=44) and healthy controls (n=36).
- Subgroup analysis compared patients with DNS (n=21) to those without DNS (n=23).
Main Results:
- COP patients showed significant cortical thinning in bilateral fronto-parietal lobes compared to controls.
- No significant differences in cortical shape indices were found between DNS and non-DNS subgroups.
- Cortical thinning in the right superior frontal gyrus (SFG) and bilateral rostral middle frontal gyrus (rMFG) positively correlated with Mini-Mental State Examination (MMSE) scores.
Conclusions:
- Cortical thickness is a more sensitive indicator of brain damage in COP than cortical shape.
- Thinning in specific frontal regions (right SFG, bilateral rMFG) is linked to cognitive impairment after COP exposure.
- These findings highlight the utility of cortical thickness analysis in assessing COP-related brain injury.
