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Overview of Exosomes

Overview of Exosomes

Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...

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Related Experiment Video

Updated: Aug 11, 2025

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Preparation of Exosomes for siRNA Delivery to Cancer Cells

Published on: December 5, 2018

Exosomes; multifaceted nanoplatform for targeting brain cancers.

Narges Mardi¹, Fatemeh Salahpour-Anarjan², Mahdieh Nemati²

¹Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

|February 2, 2023

Summary

Exosomes (Exos) offer a promising solution for brain tumor therapy by crossing the blood-brain barrier (BBB). These extracellular vesicles can deliver therapeutic agents, enhancing treatment efficacy for challenging neurological conditions.

Keywords:

Blood-brain-barrier crossing Brain tumor Engineered exosomes Targeted delivery approaches

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Last Updated: Aug 11, 2025

Preparation of Exosomes for siRNA Delivery to Cancer Cells

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Published on: December 5, 2018

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Isolation and Characterization of Exosomes Derived from Mouse Spleen Tissues

Isolation and Characterization of Exosomes Derived from Mouse Spleen Tissues

Published on: September 20, 2024

Area of Science:

Neuroscience
Biotechnology
Nanomedicine

Background:

Anaplastic brain changes pose therapeutic challenges due to neural tissue complexity and the blood-brain barrier (BBB).
The BBB restricts the passage of macromolecules and therapeutic agents into the brain, limiting treatment effectiveness.
Exosomes (Exos), a type of extracellular vesicle, are being explored for their potential to overcome these delivery limitations.

Purpose of the Study:

To review recent advances in utilizing exosomes for brain tumor therapy.
To highlight the potential of exosomes as a smart delivery platform for brain-penetrant therapeutics.
To discuss the application of exosomes in overcoming the blood-brain barrier for enhanced drug delivery.

Main Methods:

Literature review of recent studies on exosome-based drug delivery for brain tumors.
Analysis of exosome physicochemical properties and cargo-loading capabilities.
Evaluation of exosome efficacy in penetrating the blood-brain barrier and targeting brain tumors.

Main Results:

Exosomes demonstrate unique physicochemical properties suitable for drug delivery and therapeutic applications.
Exosomes have shown potential in enabling the brain penetration of therapeutic cargos, including bioactive factors and chemotherapeutics.
Smart delivery strategies involving exosomes can significantly increase therapeutic delivery efficiency and outcomes for brain tumors.

Conclusions:

Exosomes represent a promising, natural nanoplatform for overcoming the blood-brain barrier in brain tumor treatment.
The application of exosomes, particularly with smart delivery approaches, holds significant potential for improving therapeutic outcomes in neuro-oncology.
Further research into exosome-based therapies is warranted to fully exploit their capabilities for treating complex brain conditions.