Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Distinct Electrophysiological Mechanisms in the Cortico-Striatal Circuit of LID Rats.

Biology·2026
Same author

Single-Cell RNA Sequencing Reveals Lactylation Modifications in Neuroblastoma and the Construction of a Prognostic Model.

Molecules (Basel, Switzerland)·2026
Same author

Toward Optimizing Thalamic Deep Brain Stimulation for Cortical Modulation: A Surrogate Brain Approach.

bioRxiv : the preprint server for biology·2026
Same author

Therapeutic Potential of Group 2 Innate Lymphoid Cells in Neuroinflammatory Diseases.

Scandinavian journal of immunology·2026
Same author

Preoperative Coagulation Indicators Predict Prolonged Mechanical Ventilation in Acute Type a Aortic Dissection.

Annals of vascular surgery·2026
Same author

An Integrated Method for CFRP Drilling Quality Prediction and Multi-Objective Optimization.

Materials (Basel, Switzerland)·2026

Related Experiment Video

Updated: Aug 11, 2025

Whole Cell Patch Clamp for Investigating the Mechanisms of Infrared Neural Stimulation
08:58

Whole Cell Patch Clamp for Investigating the Mechanisms of Infrared Neural Stimulation

Published on: July 31, 2013

21.1K

Infrared neural stimulation in human cerebral cortex.

Li Pan1, An Ping2, Kenneth E Schriver3

  • 1Qiushi Academy for Advanced Studies (QAAS), Zhejiang University, Hangzhou, China; Key Laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou, China.

Brain Stimulation
|February 2, 2023
PubMed
Summary

Infrared Neural Stimulation (INS) precisely targets human brain circuits, showing focal responses and providing damage threshold estimates. This optical method offers a promising approach for future precision medicine therapies.

Keywords:
Cerebral cortexCortical connectionsInfrared neural stimulationOptical imagingThermal damage

More Related Videos

Exploring Cognitive Functions in Babies, Children & Adults with Near Infrared Spectroscopy
12:40

Exploring Cognitive Functions in Babies, Children & Adults with Near Infrared Spectroscopy

Published on: July 28, 2009

20.6K
A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
08:23

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

11.2K

Related Experiment Videos

Last Updated: Aug 11, 2025

Whole Cell Patch Clamp for Investigating the Mechanisms of Infrared Neural Stimulation
08:58

Whole Cell Patch Clamp for Investigating the Mechanisms of Infrared Neural Stimulation

Published on: July 31, 2013

21.1K
Exploring Cognitive Functions in Babies, Children & Adults with Near Infrared Spectroscopy
12:40

Exploring Cognitive Functions in Babies, Children & Adults with Near Infrared Spectroscopy

Published on: July 28, 2009

20.6K
A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
08:23

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

11.2K

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Optical Technologies

Background:

  • Electrical stimulation is established for treating neurological disorders like Parkinson's.
  • Targeting mesoscale functional nodes in the human brain requires precise stimulation methods.
  • Infrared Neural Stimulation (INS) uses focused heat pulses for neural activation.

Purpose of the Study:

  • To assess the efficacy of INS on the human cerebral cortex during surgery.
  • To determine the damage thresholds for INS in human cortical tissue.

Main Methods:

  • Five epilepsy patients undergoing lobectomy participated.
  • A combined INS and intrinsic signal optical imaging (OI) system was used.
  • INS was applied to the somatosensory cortex at varying intensities (0.2–0.8 J/cm²).
  • Histological analysis evaluated tissue damage.

Main Results:

  • INS induced highly focal (millimeter-scale) responses in the human cortex, similar to primate studies.
  • Nearby cortical sites showed relative suppression.
  • Intensity-dependent responses were observed.
  • Damage threshold estimates for human cortical tissue were established.

Conclusions:

  • This study demonstrates the first application of INS to the human central nervous system (CNS).
  • INS feasibility was shown for stimulating single cortical nodes and associated sites.
  • INS is a promising tool for selective stimulation of human brain circuits, advancing precision medicine.