Electron transfer-based antioxidant nanozymes: Emerging therapeutics for inflammatory diseases

Area of Science:

• Biomedical Engineering
• Materials Science
• Nanotechnology

Background:

• Inflammatory diseases are characterized by elevated reactive oxygen species (ROS).
• Excess ROS contribute to macrophage polarization, DNA damage, and cellular damage, exacerbating inflammation.
• Scavenging ROS via antioxidant strategies is crucial for managing inflammatory conditions.

Purpose of the Study:

• To review the fundamental knowledge of ROS and associated diseases.
• To summarize active centers for developing antioxidant nanozymes.
• To discuss strategies for enhancing nanozyme catalytic activity and their therapeutic applications.

Main Methods:

• Review of literature on ROS, inflammatory diseases, and nanozyme development.
• Analysis of strategies for designing antioxidant nanozymes with improved catalytic efficiency.
• Discussion of current applications of nanozymes in treating inflammatory diseases.

Main Results:

• Nanozymes inspired by natural enzymes show potential as electron transfer-based therapeutics.
• Specific active centers and design strategies can enhance nanozyme antioxidant activity.
• Developed nanozymes demonstrate efficacy in preclinical models of inflammatory diseases.

Conclusions:

• Antioxidant nanozymes represent a promising therapeutic avenue for inflammatory diseases.
• Further research into nanozyme design and application can optimize their biomedical potential.
• Nanozymes offer a novel approach to combatting oxidative stress in disease therapy.