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Updated: Aug 11, 2025

Examination of Thymic Positive and Negative Selection by Flow Cytometry
Published on: October 8, 2012
[Thymoma with Pure Red-cell Aplasia and Hypogammaglobulinemia]
Minoru Yamaki1, Mai Nishina, Toshio Noriyuki
1Department of General Thoracic Surgery, Onomichi General Hospital, Onomichi, Japan.
Abstract:
Thymoma presenting concurrent pure red-cell aplasia (PRCA) and hypogammaglobulinemia are extremely rare. A 67-year-old woman with a short of breath was referred to our hospital due to anemia and the chest abnormal shadow. Laboratory investigations revealed a hemoglobin level of 5.6 g/dl and reticulocyte percentage of 0.2%. Her serum gamma-globulin level was low. Chest computed tomography (CT) revealed a 7-cm tumor in the left upper mediastinum. We diagnosed the patient with thymoma accompanied by PRCA and hypogammaglobulinemia. The patient underwent thymectomy and PRCA has been successfully treated by postoperative cyclosporine administration. Monthly intravenous infusion of gamma-globulin has been necessary for the control of hypogammaglobulinemia. Currently, she is doing well without recurrence of thymoma or PRCA five years after the surgery.
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