[Topological principle in the study of microcirculatory structuro-functional units]

Area of Science:

• Physiology
• Anatomy
• Biophysics

Context:

• Microcirculation research traditionally focuses on individual vessel types.
• Understanding the integrated transport of fluids within tissues remains a challenge.
• The peritoneum offers a complex model for studying inter-organ transport dynamics.

Purpose:

• To introduce and validate a topological approach for analyzing microcirculatory systems.
• To elucidate the spatial-time interrelations of vascular and lymphatic transport in tissues.
• To investigate the role of interstitial space in mediating hemato-lymphatic interactions.

Summary:

• The study proposes a topological methodology to examine the morphological basis of microcirculation.
• It interprets regularly repeating transport communication ensembles as structural-functional modules within organs.
• Analysis of hemato-lymphatic interactions within these modules integrates transmural, interstitial, and axial transport processes.
• Fluid movement in tissues is characterized as oscillatory, regulated by lymphatic microvessel activity.
• Capillary blood volume regulation is linked to interstitial space conditions and transmural transport intensity.

Impact:

• This approach provides a framework for understanding tissue fluid dynamics as integrated modules.
• It offers new insights into the regulation of blood and lymph transport.
• The topological method is applicable to analyzing transport interrelations across various organ tissues.