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Assessment of Vascular Regeneration in the CNS Using the Mouse Retina
Published on: June 23, 2014
Newer Updates in Pediatric Vascular Diseases
Zachary M Wilseck1, Leanne Y Lin1, Neeraj Chaudhary2
1Department of Radiology, University of Michigan, Ann Arbor, MI.
Insights
Pediatric neurovascular pathologies affect the central nervous system (CNS) in children. Advanced imaging techniques like Ultrasound, CT, MRI, and digital subtraction angiography (DSA) are crucial for diagnosis and treatment planning.
Area of Science:
- Pediatric Neurology
- Neuroradiology
- Vascular Imaging
Background:
- Pediatric neurovascular pathology involves the central nervous system (CNS), presenting uniquely in children compared to adults.
- These conditions can be isolated or part of broader syndromes, necessitating specialized diagnostic approaches.
Approach:
- Utilizes non-invasive imaging modalities such as Ultrasound, CT, and MRI for diagnosis, treatment planning, and follow-up.
- Digital subtraction angiography (DSA) serves as a diagnostic and therapeutic tool.
- Emphasizes multidisciplinary collaboration among pediatricians and specialists.
Key Points:
- Imaging modality selection depends on patient age, diagnostic urgency, and availability.
- Each imaging technique has varying sensitivities and specificities for different neurovascular pathologies.
- Understanding imaging findings, natural history, and treatment is vital for effective management.
Conclusions:
- This review provides an overview of pediatric neurovascular pathologies.
- Highlights pathognomonic imaging findings and discusses endovascular treatment options.
- A comprehensive approach integrating imaging and clinical expertise is essential for managing pediatric cerebrovascular disease.
Abstract:
Pediatric neurovascular pathology directly involves or is in close proximity to the central nervous system (CNS). These vascular pathologies can occur in isolation or in association with broader syndromes. While some vascular pathologies are unique to the pediatric population, the full spectrum of adult neurovascular lesions can also affect children however, may present differently both clinically and on diagnostic imaging. Non-invasive (Ultrasound, CT, MRI) imaging plays a critical role in the diagnosis, treatment planning, and follow-up of vascular lesions involving the CNS. The modality can be chosen based on the age of the child, urgency of diagnosis, and local availability. Each modality has sensitivities and specificities which vary based on the location and imaging findings of a specific neurovascular pathology. In addition to non-invasive options, digital subtraction angiography (DSA) may be used as both a diagnostic and therapeutic imaging method for pediatric vascular lesions of the central nervous system. The diagnosis and management of pediatric cerebrovascular disease requires the close collaboration between pediatricians and pediatric specialists including neuroradiologists, neurologists, neurosurgeons, cardiologists, neurointerventionalists, and anesthesiologists among others. A detailed understanding of imaging findings, natural history, and treatment options is essential to guide and monitor imaging and treatment. The goal of this review is to provide the reader with an overview on pediatric neurovascular pathologies, provide examples of pathognomonic imaging findings, and present a brief review of endovascular treatment options, if applicable.
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