Functional System Based on Glycyrrhizic Acid Supramolecular Hydrogel: Toward Polymorph Control, Stabilization, and
Weiqi Liu1, Zhiqiang Li1, Zixuan Wang1
1Guangdong Provincial Key Lab of Green Chemical Product Technology, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou510640, China.
Natural glycyrrhetinic acid hydrogels effectively control and stabilize the metastable gamma form of pyrazinamide. This drug delivery system offers pH-responsive, targeted release, enhancing drug efficacy and stability.
Area of Science:
- Materials Science
- Pharmaceutical Science
- Biotechnology
Background:
- Drug delivery systems (DDS) using natural supramolecular hydrogels offer biocompatibility and tunable performance.
- Designing functional hydrogel DDS with controlled drug interactions remains a challenge.
Purpose of the Study:
- To develop a simple and efficient hydrogel DDS using glycyrrhetinic acid (GA) gel to encapsulate and control pyrazinamide (PZA).
- To investigate the polymorph control, stabilization, and pH-responsive release of PZA within the GA hydrogel.
Main Methods:
- Encapsulation of pyrazinamide (PZA) in a natural glycyrrhetinic acid (GA) hydrogel.
- Characterization using Powder X-ray diffraction (PXRD), spectral analysis, and molecular dynamics simulation.
- In vitro drug release studies under varying pH conditions.
Main Results:
- GA gel successfully produced and stabilized the metastable gamma form of PZA.
- Carboxyl-amide interactions at the gel-drug interface mediated PZA polymorphism and enhanced stability for 3 months.
- The GA hydrogel demonstrated pH-responsive, targeted release of PZA.
Conclusions:
- Glycyrrhetinic acid hydrogels provide a promising platform for DDS with integrated polymorph control and stabilization.
- The developed system enhances drug stability and enables targeted, pH-responsive drug delivery.
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