Related Experiment Video

Updated: Aug 11, 2025

Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice
08:02

Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice

Published on: October 19, 2013

18.5K

Vascular and pulmonary effects of ibuprofen on neonatal lung development

Xueyu Chen1, Dongshan Han1, Xuan Wang1

  • 1Laboratory of Neonatology, Department of Neonatology, Affiliated Shenzhen Maternity and Child Healthcare Hospital, The First School of Clinical Medicine, Southern Medical University, Shenzhen, China.

Respiratory Research
|February 2, 2023
PubMed

Insights

Ibuprofen, used for premature infants, may harm neonatal lung development by inhibiting blood vessel growth. However, it also reduces inflammation and structural damage in experimental bronchopulmonary dysplasia (BPD).

Area of Science:

  • Neonatal physiology and pharmacology
  • Pulmonary medicine and developmental biology
  • Endothelial cell biology and angiogenesis

Background:

  • Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to close patent ductus arteriosus (PDA) in premature infants.
  • NSAID use in neonates may negatively impact lung development, potentially causing bronchopulmonary dysplasia (BPD).

Purpose of the Study:

  • To investigate ibuprofen's effects on angiogenesis in human umbilical cord vein endothelial cells (HUVECs).
  • To evaluate the therapeutic potential of ibuprofen in a rat model of hyperoxia-induced experimental BPD.

Main Methods:

  • Assessed ibuprofen's impact on HUVEC angiogenesis, including tube formation, migration, and cell proliferation.
  • Administered daily subcutaneous ibuprofen (50 mg/kg) to neonatal Wistar rats with experimental BPD.
  • Evaluated lung histopathology, growth, survival, and mRNA expression in treated rat pups.

Main Results:

  • Ibuprofen inhibited angiogenesis in HUVECs by impeding the cell cycle and promoting apoptosis.
  • In neonatal rats, ibuprofen reduced pulmonary vessel density but attenuated experimental BPD.
  • Beneficial effects in rats included reduced lung inflammation and structural abnormalities like alveolar enlargement and arteriolar wall thickening.

Conclusions:

  • Ibuprofen exhibits dual effects on neonatal lung development: it impairs angiogenesis but offers benefits for alveolarization and inflammation.
  • Caution is advised when considering ibuprofen for premature infants with BPD due to potential adverse effects on lung angiogenesis.
Abstract

Keywords:
AlveolarizationAngiogenesisBronchopulmonary dysplasiaCell cycle arrestLung inflammationNonsteroidal anti-inflammatory drugPulmonary arterial hypertension

More Related Videos

A Preterm Rat Model for Pain Studies01:37

A Preterm Rat Model for Pain Studies

Published on: February 9, 2024

463
An Experimental System to Study Mechanotransduction in Fetal Lung Cells09:35

An Experimental System to Study Mechanotransduction in Fetal Lung Cells

Published on: February 16, 2012

13.1K

Related Concept Videos

Factors Affecting Pulmonary Ventilation01:19

Factors Affecting Pulmonary Ventilation

Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
1.5K
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.6K
Fetal Circulation01:14

Fetal Circulation

Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
1.1K
Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
251