Related Experiment Video

Updated: Aug 11, 2025

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
04:37

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

221

Clinical outcomes in COVID-19 among patients with hypertension in the Philippine CORONA Study

Adrian I Espiritu1,2,3, Ma Sergia Fatima P Sucaldito4, Deborah Ignacia D Ona5

  • 1Division of Adult Neurology, Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines. aiespiritu@up.edu.ph.

European Journal of Medical Research
|February 3, 2023
PubMed

Insights

Hypertension significantly increases the risk of severe outcomes in COVID-19 patients, including death, respiratory failure, and ICU admission. This highlights the importance of managing hypertension for better COVID-19 prognosis.

Area of Science:

  • Epidemiology
  • Infectious Diseases
  • Cardiovascular Medicine

Background:

  • Hypertension is a prevalent comorbidity globally.
  • The impact of hypertension on coronavirus disease 2019 (COVID-19) clinical outcomes requires further elucidation.
  • Understanding these associations is crucial for patient management and public health strategies.

Purpose of the Study:

  • To investigate the association between hypertension and clinical outcomes in a large cohort of hospitalized COVID-19 patients in the Philippines.
  • To determine if hypertension is an independent risk factor for adverse outcomes in COVID-19.

Main Methods:

  • Retrospective cohort study involving 10,881 patients admitted with COVID-19 across 37 hospitals in the Philippines.
  • Data collected from February to December 2020.
  • Statistical analyses included regression and time-to-event analyses, adjusted for multiple confounders.

Main Results:

  • 33.5% of the 10,881 patients had hypertension.
  • Hypertension was independently associated with significantly increased odds of in-hospital mortality (OR 1.33), respiratory failure (OR 1.99), ICU admission (OR 2.16), and severe/critical COVID-19 (OR 1.57).
  • Time-to-event analysis revealed hypertension was linked to shorter times to mortality, respiratory failure, and ICU admission.

Conclusions:

  • Hypertension is confirmed as an independent risk factor for worse clinical outcomes in hospitalized COVID-19 patients.
  • Findings indicate increased risks for mortality, respiratory failure, ICU admission, and severe disease among hypertensive COVID-19 patients.
  • Further research is recommended to explore the influence of hypertension characteristics (e.g., severity, control) on COVID-19 outcomes.
Abstract

Keywords:
COVID-19Clinical outcomesHypertensionICU AdmissionMortalityRespiratory failureRetrospective cohortSARS-CoV-2

More Related Videos

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug05:57

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug

Published on: May 17, 2024

824
Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

3.4K

Related Concept Videos

Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
36
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
29
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
37
Hypertension V: Nursing Management01:23

Hypertension V: Nursing Management

The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
25
Hypertension IV: Drug Therapy and Lifestyle Modifications01:28

Hypertension IV: Drug Therapy and Lifestyle Modifications

Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...
26
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
2.2K