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Metal-Organic Framework in Pharmaceutical Drug Delivery
Sudipto Kundu1, Akey Krishna Swaroop1, Jubie Selvaraj1
1Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research Ooty, Nilgiris, Tamilnadu, India.
Current Topics in Medicinal Chemistry
|February 3, 2023
Summary
Metal-organic frameworks (MOFs) offer tuneable properties for advanced drug delivery systems (DDSs). MOF composites enhance functionalities like triggered release and diagnostics, expanding biomedical applications.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Metal-organic frameworks (MOFs) are porous, crystalline materials constructed from metal ions/clusters and organic ligands.
- MOFs are increasingly utilized in drug delivery systems (DDSs) due to their tunable porosity, size, shape, and surface functionalization.
- Their capacity for high drug loading and controlled release makes them attractive for protecting and delivering sensitive therapeutics.
Purpose of the Study:
- To review the classification and applications of MOFs in drug delivery.
- To explore the development of MOF-composite materials for enhanced functionalities.
- To discuss the potential and limitations of MOFs in various biomedical applications, including photodynamic therapy and electrochemical biosensing.
Main Methods:
- Classification of MOFs based on metal and ligand composition for DDSs.
- Incorporation of guest materials and functionalized nanoparticles to create MOF-composites.
- Review of MOF applications in drug delivery, photodynamic treatment, and electrochemical biosensing.
Main Results:
- MOFs exhibit significant drug absorption capacity and slow-release properties.
- MOF-composites offer enhanced functionalities, including externally triggered release, improved pharmacokinetics, and diagnostic capabilities.
- MOF-based composites demonstrate improved electrical conductivity and catalytic activity for biosensing applications.
Conclusions:
- Engineered MOFs with controlled sizes hold great promise for diverse biomedical applications.
- MOF-composites significantly expand the therapeutic and diagnostic potential of MOFs.
- Further development of MOF materials is needed to overcome limitations in areas like electrochemical biosensing.
Keywords:
Antitumor agentsBiomedical application.BiosensingDrug delivery systemMetal organic frameworkPhotodynamic treatmentMore Related Videos
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