Related Experiment Video
Updated: Oct 13, 2026

Heterotypic Three-dimensional In Vitro Modeling of Stromal-Epithelial Interactions During Ovarian Cancer Initiation and Progression
Published on: August 28, 2012
[Overlap behaviour as a cell-biology characteristic of cultivated ovarian cancer cells]
1Klinik für Gynäkologie und Geburtshilfe, Bereichs Medizin der Karl-Marx-Universität Leipzig.
Abstract:
The in vitro growth behaviour of ovarian cancer cells is investigated regarding its ability to characterize this tumor biologically. Out of 60 patients suffering from ovarian cancer with different extension and histologic types 79 in vitro cell cultures were cultivated from either tumor biopsies, ascites or pleura effusions. The overlap index of each culture is calculated by the ratio of actually observed to as a maximum expected nuclear overlaps and is compared to parameters being acknowledged characterization of ovarian carcinomas. Correlations were found between overlap behaviour and other typical parameters such as histologic type, grading, and tumor staging. Beside some other parameters nuclear overlap index seems to be appropriate for characterization of neoplastic ovarian tumors.
More Related Videos
14:25Assessment of Ovarian Cancer Spheroid Attachment and Invasion of Mesothelial Cells in Real Time
Published on: May 20, 2014
08:26Strategy for Biobanking of Ovarian Cancer Organoids: Addressing the Interpatient Heterogeneity across Histological Subtypes and Disease Stages
Published on: February 23, 2024
Related Concept Videos
Oogenesis
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...