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Association of RNA m7G Modification Gene Polymorphisms with Pediatric Glioma Risk.

Jinhong Zhu1,2, Xiaoping Liu3, Wei Chen1

  • 1Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou, 510623 Guangdong, China.

Biomed Research International
|February 3, 2023
PubMed
Summary
This summary is machine-generated.

Genetic variations in the WDR4 gene are linked to a lower risk of childhood glioma in Chinese Han children. Specifically, the WDR4 rs15736 polymorphism was associated with reduced glioma susceptibility.

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Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • Childhood glioma is a major cause of cancer mortality.
  • The genetic factors influencing glioma risk are not fully understood.
  • The METTL1-WDR4 complex plays a role in tumorigenesis via RNA methylation.

Purpose of the Study:

  • To investigate the association between polymorphisms in the METTL1 and WDR4 genes and glioma risk in Chinese Han children.
  • To identify specific genetic variants contributing to glioma susceptibility.

Main Methods:

  • Case-control study involving 314 glioma cases and 380 controls.
  • Genotyping of eight polymorphisms (3 in METTL1, 5 in WDR4) using TaqMan assay.
  • Statistical analysis including adjusted odds ratios and expression quantitative trait locus (eQTL) analysis.

Main Results:

  • The WDR4 rs15736 polymorphism was significantly associated with reduced glioma risk (OR=0.63, P=0.023).
  • This association remained significant in subgroups including older children, girls, astrocytic tumors, and low-grade gliomas.
  • eQTL analysis indicated rs15736 affects WDR4 and CBS gene expression.

Conclusions:

  • WDR4 gene polymorphisms, particularly rs15736, are associated with glioma susceptibility in Chinese Han children.
  • The findings suggest a potential causal link between WDR4 variants and childhood glioma.
  • This research contributes to understanding the genetic basis of childhood glioma.