Related Experiment Video
Updated: Aug 11, 2025
08:58
Artificial Intelligence Approaches to Assessing Primary Cilia
Published on: May 1, 2021
3.6K
Primary cilia-associated protein IFT172 in ciliopathies
Nan-Xi Zheng1, Ya-Ting Miao1, Xi Zhang1
1Department of Psychiatry, National Clinical Research Centre for Mental Health, The Second Xiangya Hospital, Central South University, Changsha, China.
Frontiers in Cell and Developmental Biology
|February 3, 2023
Summary
Intraflagellar transport 172 (IFT172) is crucial for cilia function and linked to rare diseases like Mainzer-Saldino syndrome. Understanding IFT172
Area of Science:
- Cell Biology
- Genetics
- Developmental Biology
Background:
- Cilia are vital cell structures involved in signaling and development.
- Primary cilia dysfunction causes diverse congenital diseases (ciliopathies).
- Intraflagellar transport (IFT) maintains cilia structure and function.
Purpose of the Study:
- To review the genetic and protein characteristics of IFT172.
- To elucidate the role of IFT172 in intraflagellar transport.
- To provide insights into IFT172-related ciliopathies.
Main Methods:
- Literature review of genetic and protein data.
- Analysis of IFT172's role in intraflagellar transport mechanisms.
- Synthesis of findings related to ciliopathies.
Main Results:
- IFT172 is a key IFT protein implicated in rare ciliopathies.
- Disrupted IFT172 function contributes to cilia abnormalities.
- IFT172 is essential for maintaining cilia homeostasis.
Conclusions:
- IFT172 plays a critical role in cilia function and development.
- Further research into IFT172 is needed to understand associated ciliopathies.
- IFT172 represents a potential therapeutic target for ciliopathies.
Related Concept Videos
01:22Microtubules in Signaling
1.8K
The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...
1.8K
01:31Types of Intermediate Filaments
3.8K
The intermediate filaments are an essential component of the cytoskeleton. Presently six types of intermediate filament have been identified. Type I and II are acidic and basic keratin proteins. Type III is of mesodermal origin and comprises four proteins: vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Vimentin is commonly found in mesenchymal cells, desmin in muscle cells, GFAP in astrocytes, while peripherin is found in peripheral nervous system neurons (PNS). Type...
3.8K
01:23Cystic Fibrosis: Pathogenesis
321
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
321
01:39Mechanism of Filopodia Formation
2.4K
Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
2.4K
01:02Role of Septins
1.8K
Septins are the recently discovered fourth major protein component of the cytoskeleton, along with microfilaments, microtubules, and intermediate filaments. These proteins can associate with other cytoskeletal filaments and carry out varied roles or can be free-floating in the cytoplasm.
Cellular Functions of Septins
Recent studies have revealed the multifaceted roles of septins in various cellular processes such as cytokinesis, ciliogenesis, and neurogenesis. Septins act as scaffolds and...
Cellular Functions of Septins
Recent studies have revealed the multifaceted roles of septins in various cellular processes such as cytokinesis, ciliogenesis, and neurogenesis. Septins act as scaffolds and...
1.8K
01:09Cytoskeletal Linker Proteins - Plakins
2.4K
Plakins are large proteins with binding domains for microtubules, microfilaments, intermediate filaments, and membrane-associated protein complexes at cell junctions. Plakin functions are evolutionarily conserved and are primarily involved in organizing the different components of the cytoskeleton by crosslinking them to each other and connecting them to the cell-matrix and cell adhesion complexes. They are also known to interact with signal transducers, serve as scaffolds for signaling...
2.4K