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Updated: Aug 11, 2025

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
Published on: July 17, 2012
High-density diffuse correlation tomography with enhanced depth localization and minimal surface artefacts
Ria Paul1, K Murali1, Hari M Varma1
1Indian Institute of Technology Bombay (IITB), Mumbai-400076, India.
Abstract:
A spatially weighted filter applied to both the measurement and the Jacobian is proposed for high-density diffuse correlation tomography (DCT) to remove unwanted extracerebral interferences and artefacts along with better depth localization in the reconstructed blood flow images. High-density DCT is implemented by appropriate modification of recently introduced Multi-speckle Diffuse Correlation Spectroscopy (M-DCS) system. Additionally, we have used autocorrelation measurements at multiple delay-times in an iterative manner to improve the reconstruction results. The proposed scheme has been validated by simulations, phantom experiments and in-vivo human experiments.
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