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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Updated: Aug 11, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Systemic Sarcoidosis Presenting in a Scar.

Amy Xiao1, Lauryn M Falcone2, Joseph C English Iii2

  • 1School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Case Reports in Dermatological Medicine
|February 3, 2023
PubMed
Summary
This summary is machine-generated.

Cutaneous sarcoidosis, particularly scar sarcoidosis, can indicate underlying pulmonary sarcoidosis. Early skin biopsy is crucial for diagnosing systemic sarcoidosis and improving patient outcomes.

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Area of Science:

  • Dermatology
  • Pulmonology
  • Pathology

Background:

  • Cutaneous sarcoidosis often presents asymptomatically, but 40% of patients have systemic involvement, primarily affecting lungs, heart, eyes, and nervous system.
  • Diagnosing sarcoidosis early is challenging due to varied presentations, asymptomatic cases, and lack of a definitive non-biopsy test.

Observation:

  • A woman in her 50s presented with scar sarcoidosis as reddish-brown macules around a skin graft scar.
  • Dermal biopsy revealed non-necrotizing granulomas, characteristic of sarcoidosis.

Findings:

  • The scar sarcoidosis led to the diagnosis of stage II pulmonary sarcoidosis.
  • Chest CT showed extensive hilar lymphadenopathy, confirming systemic involvement.

Implications:

  • This case highlights scar sarcoidosis as a potential indicator of systemic sarcoidosis.
  • Emphasizes the importance of considering sarcoidosis in skin changes near scars and the necessity of early biopsy for timely diagnosis and treatment.
  • Prompt diagnosis facilitates earlier systemic evaluation and potentially better patient outcomes.