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Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material

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Published on: August 1, 2018

Multifocal/multicentric breast cancer: Does each focus matter?

Ying Tong¹, Feixiang Sun¹, Chuanpeng Zhang¹

¹Jiangsu Breast Disease Center, Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital, Nanjing, China.

Cancer Medicine

|February 3, 2023

Summary

This summary is machine-generated.

Aggregate tumor dimensions better predict multifocal (MF) and multicentric (MC) breast cancer behavior than the largest tumor alone. Examining each lesion is crucial due to significant intertumoral heterogeneity in MF/MC breast cancers.

Keywords:

breast cancer intertumoral heterogeneity multicentrical multifocal tumor stage

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Area of Science:

Oncology
Breast Cancer Research
Tumor Staging

Background:

Multifocal (MF) and multicentric (MC) breast cancer diagnoses are increasing due to advanced imaging.
Current staging relies on the largest tumor's dimension and pathology in MF/MC cases.

Purpose of the Study:

To compare aggregate vs. largest tumor dimensions for predicting MF/MC breast cancer behavior.
To investigate histological and biological heterogeneity among separate foci in MF/MC breast cancers.

Main Methods:

Retrospective analysis of 121 MF/MC and 484 unifocal breast cancer patients.
T staging assessed using largest lesion and aggregate dimensions.
Intertumoral heterogeneity evaluated via pathological type, grade, and molecular subtypes.

Main Results:

Aggregate dimensions upstaged 63 MF/MC patients and negated multiplicity's effect on lymph node positivity.
Pathological type, histological grade, and molecular subtype mismatches observed between foci (9.9%, 4.1%, 8.3%).

Conclusions:

Aggregate tumor dimensions may better predict MF/MC breast cancer metastasis risk.
Current staging systems may need revision for MF/MC breast cancers.
Intertumoral heterogeneity necessitates individual lesion assessment in MF/MC breast cancers.