Anticancer Phytochemical-Based Nanoformulations: Therapeutic Intervention in Cancer Cell Lines

Area of Science:

• Oncology
• Nanotechnology
• Pharmacology

Background:

• Phytochemicals offer potential for treating resistant cancers.
• Nano-based carriers enhance phytochemical delivery to target sites.
• Phytochemical nanoformulations demonstrate improved efficacy over single agents in preclinical models.

Approach:

• This review synthesizes research on phytochemical-based nanoformulations for cancer therapy.
• Investigates synergistic effects on cancer cell lines (MCF-7, 4T1) and in vivo models (glioma).
• Examines mechanisms including p53 apoptosis, caspase activation, cell cycle arrest, and pathway inhibition (Akt/mTOR).

Key Points:

• Phytochemical nanoformulations exhibit enhanced cytotoxicity and synergistic inhibition of cancer cell growth.
• Demonstrated efficacy in various cancer types, including breast, glioma, cervical, colorectal, and tongue squamous cell carcinoma.
• Mechanisms involve apoptosis induction, cell cycle arrest, and specific pathway modulation.

Conclusions:

• Phytochemical nanoformulations represent a promising therapeutic strategy for diverse cancers.
• Potential to halt or slow disease progression and reduce chemotherapy-induced toxicities.
• Further clinical development of these nanoformulations is warranted for improved cancer patient management.