Inflammaging as a target for healthy ageing.
Ben Dugan1,2, Jessica Conway1,2, Niharika A Duggal1,2
1Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
Age and Ageing
|February 3, 2023
Summary
As people live longer, chronic inflammation (inflammaging) increases disease risk. This review explores interventions like diet, supplements, and senolytics to combat inflammaging and promote healthy aging.
Area of Science:
- Gerontology and immunology
- Chronic disease research
- Aging and healthspan
Background:
- Increasing life expectancy contrasts with stagnant healthy life expectancy, creating a global health burden.
- Aging is characterized by chronic, low-grade systemic inflammation, known as inflammaging.
- Inflammaging is a significant risk factor for age-associated chronic diseases and reduced healthspan.
Approach:
- Comprehensive review of current literature on inflammaging and age-related diseases.
- Formulation of hypotheses linking inflammaging to chronic disease development in older adults.
- Exploration of non-pharmacological and pharmacological interventions targeting inflammaging.
Key Points:
- Non-pharmacological strategies include diet, nutraceuticals, phytochemicals, physical activity, and microbiome therapies.
- Pharmacological interventions encompass caloric restriction mimetics and p38 MAPK inhibitors.
- Novel targets like senolytics offer potential for combating inflammaging and improving healthspan.
Conclusions:
- Inflammaging is a central driver of age-related chronic diseases and ill health.
- Targeting inflammaging through various interventions can restore health and optimize the aging process.
- Interventions aim to increase healthy lifespan by mitigating the effects of chronic inflammation.
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