Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

2.0K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
2.0K
Pigmentation01:19

Pigmentation

2.5K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
2.5K
Skin Cancer01:30

Skin Cancer

4.4K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.4K
Cardiovascular System Abnormal Findings I: Inspection and Palpation01:29

Cardiovascular System Abnormal Findings I: Inspection and Palpation

469
In a cardiovascular examination, inspection and palpation are crucial for identifying abnormalities.
Abnormal findings observed during an inspection
469
Assessment of the Cardiovascular System III: Palpation01:27

Assessment of the Cardiovascular System III: Palpation

413
Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...
413
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

23
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
23

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Psychiatric Outcomes after GLP-1 Receptor Agonists versus Metformin in Hidradenitis Suppurativa.

Skin appendage disorders·2026
Same author

Patterns of excess and cause-specific mortality in vulvar squamous cell carcinoma: a Surveillance, Epidemiology, and End Results program population-based study.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society·2026
Same author

Therapeutic Infliximab Levels Are Associated With Improved Clinical Outcomes in Hidradenitis Suppurativa: A Pilot Retrospective Cohort Study.

Journal of the American Academy of Dermatology·2026
Same author

Drug-related pseudolymphoma: Insights from the Food and Drug Administration Adverse Event Reporting System.

Journal of the American Academy of Dermatology·2026
Same author

Biologic agents for immune checkpoint inhibitor-associated cutaneous adverse events: A retrospective cohort study at a tertiary referral center.

Journal of the American Academy of Dermatology·2026
Same author

Racial disparities in survival among patients with vulvar melanoma: A National Cancer Database analysis.

Journal of the American Academy of Dermatology·2026
Same journal

Does taking BP medicine at night (vs morning) result in fewer cardiovascular events?

The Journal of family practice·2023
Same journal

Preventing RSV in children and adults: A vaccine update.

The Journal of family practice·2023
Same journal

Essential oils: How safe? How effective?

The Journal of family practice·2023
Same journal

51-year-old woman • History of Graves disease • General fatigue, palpitations, and hand tremors • Dx?

The Journal of family practice·2023
Same journal

Renewing the dream.

The Journal of family practice·2023
Same journal

55-year-old woman • Myalgias and progressive symmetrical proximal weakness • History of unilateral renal agenesis, type 2 diabetes, and hyperlipidemia • Dx?

The Journal of family practice·2023
See all related articles

Related Experiment Video

Updated: Aug 11, 2025

Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid
04:12

Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid

Published on: January 19, 2024

999

Blue-black hyperpigmentation on the extremities.

Nora S Ali1, Mauricio F Jin1, David A Wetter1

  • 1Dermatology Consultants, PA, Saint Paul, MN (Dr. Ali); Department of Dermatology, Mayo Clinic, Rochester, MN (Dr. Wetter); Mayo Clinic Alix School of Medicine, Rochester, MN (Mr. Jin).

The Journal of Family Practice
|February 3, 2023
PubMed
Summary
This summary is machine-generated.

Understanding the cause of a condition is crucial for accurate diagnosis. This study emphasizes the importance of etiological investigation in medical diagnostics.

More Related Videos

Author Spotlight: A Multi-Depth Porcine Model for Comprehensive Study of Burn Injuries and Healing Processes
02:49

Author Spotlight: A Multi-Depth Porcine Model for Comprehensive Study of Burn Injuries and Healing Processes

Published on: February 23, 2024

1.2K
Quantification of Hypopigmentation Activity In Vitro
06:08

Quantification of Hypopigmentation Activity In Vitro

Published on: March 6, 2019

11.4K

Related Experiment Videos

Last Updated: Aug 11, 2025

Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid
04:12

Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid

Published on: January 19, 2024

999
Author Spotlight: A Multi-Depth Porcine Model for Comprehensive Study of Burn Injuries and Healing Processes
02:49

Author Spotlight: A Multi-Depth Porcine Model for Comprehensive Study of Burn Injuries and Healing Processes

Published on: February 23, 2024

1.2K
Quantification of Hypopigmentation Activity In Vitro
06:08

Quantification of Hypopigmentation Activity In Vitro

Published on: March 6, 2019

11.4K

Area of Science:

  • Medical Diagnostics
  • Etiology
  • Pathophysiology

Background:

  • Traditional diagnostic approaches often focus on identifying the disease entity.
  • However, determining the underlying cause (etiology) is increasingly recognized as vital for effective management.

Purpose of the Study:

  • To highlight the significance of etiological diagnosis in clinical practice.
  • To explore the shift from "what is it?" to "what caused it?" in diagnostic paradigms.

Main Methods:

  • Review of diagnostic frameworks.
  • Analysis of clinical case studies emphasizing etiological factors.
  • Literature synthesis on diagnostic advancements.

Main Results:

  • Diagnostic success is often contingent on identifying the root cause.
  • Etiological investigation provides a more comprehensive understanding of disease.
  • This approach facilitates targeted and personalized treatment strategies.

Conclusions:

  • The diagnostic process should prioritize etiological exploration.
  • A causal-based diagnostic model improves patient outcomes.
  • Future research should focus on refining methods for etiological determination.