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A review on the roles and molecular mechanisms of MAFG-AS1 in oncogenesis

Khazar Ghasempour Dabbaghi1, Noushin Mashatan2, Omid Faraz3

  • 1Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Pathology, Research and Practice
|February 3, 2023
PubMed

Insights

Long non-coding RNA MAFG-AS1 acts as an oncogene in various cancers, impacting progression and patient prognosis. This review explores its diagnostic, prognostic, and functional roles in cancer.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Long non-coding RNAs (lncRNAs) are key regulators of biological functions, including cancer.
  • MAFG-AS1, an antisense RNA to MAFG, is implicated in various human cancers.

Purpose of the Study:

  • To review the literature on MAFG-AS1's role in different cancers.
  • To discuss its diagnostic and prognostic values.
  • To provide insights into its biological functions in cancer.

Main Methods:

  • Literature review of studies on MAFG-AS1 in human cancers.
  • Analysis of MAFG-AS1's association with clinical characteristics and prognosis.
  • Examination of MAFG-AS1's molecular mechanisms.

Main Results:

  • MAFG-AS1 is overexpressed in numerous cancers and linked to poor prognosis.
  • MAFG-AS1 exhibits oncogenic activity across various cancer types.
  • Evidence suggests MAFG-AS1 influences cancer progression, EMT, and metabolism.

Conclusions:

  • MAFG-AS1 is a significant oncogene with diagnostic and prognostic implications in cancer.
  • Understanding MAFG-AS1's functions can reveal novel therapeutic targets.
  • Further research into MAFG-AS1 pathways is warranted for cancer treatment.
Keywords:
CancerMILIPMiRNANon-coding-RNAOncogenePrognosislncRNA

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