Related Experiment Video

Updated: Aug 11, 2025

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
07:16

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

Published on: September 13, 2018

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Deciphering the role of Hippo pathway in lung cancer

Soudeh Ghafouri-Fard1, Yadollah Poornajaf2, Bashdar Mahmud Hussen3

  • 1Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Pathology, Research and Practice
|February 3, 2023
PubMed

Insights

The Hippo signaling pathway regulates organ size and is implicated in lung cancer. Non-coding RNAs and anti-cancer agents modulate this pathway, offering potential therapeutic strategies for lung cancer.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • The Hippo pathway, initially identified in Drosophila, regulates organ size and is crucial for homeostasis and preventing tumorigenesis.
  • Key components include tumor suppressors like hippo (hpo) and warts (wts), and oncogenes like yorkie (yki).
  • Emerging evidence highlights the Hippo pathway's significant role in lung carcinogenesis.

Purpose of the Study:

  • To review the involvement of the Hippo signaling pathway in lung cancer progression.
  • To explore the impact of non-coding RNAs on Hippo pathway activity in lung cancer.
  • To summarize the effects of various anti-cancer agents on the Hippo pathway in the context of lung cancer.

Main Methods:

  • Literature review of recent studies on Hippo signaling in lung cancer.
  • Analysis of research investigating non-coding RNAs (miRNAs, PVT1, SFTA1P, NSCLCAT1, circ_0067741) and their interaction with the Hippo pathway.
  • Compilation of data on anti-cancer agents (gallic acid, icotinib hydrochloride, curcumin, etc.) and their mechanisms involving Hippo pathway modulation.

Main Results:

  • The Hippo pathway influences lung cancer through various mechanisms, including interactions with microRNAs (miRNAs).
  • Several non-coding RNAs are implicated in lung carcinogenesis by affecting the Hippo pathway.
  • Numerous anti-cancer agents exert their effects in lung cancer by modulating the Hippo signaling pathway.

Conclusions:

  • The Hippo signaling pathway is a critical player in lung cancer development and progression.
  • Non-coding RNAs represent a significant regulatory layer impacting the Hippo pathway in lung cancer.
  • Targeting the Hippo pathway with specific anti-cancer agents holds promise for lung cancer therapy.
Keywords:
BiomarkerDiagnosticExpressionHippo pathwayLung cancer

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