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Updated: Aug 11, 2025

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
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Prognostic significance of natural products against multidrug tumor resistance

Pankaj Garg1, Rachana Garg2, David Horne3

  • 1Department of Chemistry, GLA University, Mathura, Uttar Pradesh, 281406, India.

Cancer Letters
|February 3, 2023
PubMed

Insights

Natural dietary products offer a promising avenue for cancer prevention and management. Bioactive ingredients in these products show potential in combating various malignancies, complementing traditional treatments.

Area of Science:

  • Oncology
  • Nutritional Science
  • Pharmacology

Background:

  • Cancer is a leading global cause of mortality, with increasing incidence despite advances in conventional treatments.
  • Current cancer therapies (surgery, radiation, pharmaceuticals) have limitations in reducing mortality rates.
  • Natural products are increasingly explored as complementary or alternative strategies for cancer prevention and treatment.

Purpose of the Study:

  • To review the mechanisms of action of bioactive compounds from natural dietary products.
  • To explore the potential of these natural compounds in cancer prevention and management.
  • To highlight the role of primary prevention in global cancer control.

Main Methods:

  • Literature review of scientific studies on natural products and cancer.
  • Analysis of bioactive ingredients in dietary products.
  • Examination of proposed mechanisms of action against various cancers.

Main Results:

  • A significant proportion of current medications are derived from natural plant products.
  • Bioactive ingredients in natural dietary products exhibit diverse mechanisms against cancer.
  • Natural products show promise in both primary cancer prevention and as adjuncts in management.

Conclusions:

  • Natural product-based therapies represent a viable alternative or complementary approach to cancer treatment.
  • Dietary bioactive compounds hold significant potential for cancer prevention and management strategies.
  • Further research into natural products is crucial for advancing cancer control efforts.
Keywords:
ChemopreventionChemotherapeutic drugsDrug resistanceNatural products

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