The development of small molecules targeting methyltransferase-like 3

Area of Science:

• Biochemistry
• Molecular Biology
• Oncology

Background:

• N-methyladenosine (m6A) is the most prevalent mRNA modification in mammals.
• Methyltransferase-like 3 (METTL3) is the key enzyme regulating m6A.
• METTL3 dysregulation is linked to diverse diseases, including cancer initiation and progression.

Approach:

• Systematic review of small molecules targeting METTL3.
• Analysis of current discovery and development strategies.
• Identification of future research directions.

Key Points:

• METTL3 is a critical regulator of mRNA methylation.
• Targeting METTL3 with small molecules offers therapeutic opportunities.
• The review consolidates information on METTL3 inhibitors for researchers.

Conclusions:

• Small molecule inhibitors of METTL3 are promising therapeutic agents.
• Further development is needed to optimize METTL3-targeting drugs.
• This review provides a comprehensive resource for METTL3 research.