Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Combination therapy in sarcomas and the challenges of heterogeneity.

Chinese clinical oncology·2026
Same author

Brigimadlin Versus Doxorubicin in Advanced Dedifferentiated Liposarcoma: Efficacy, Safety and Translational Data from Brightline-1, a Randomized Phase 2/3 Trial.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

Intratumoral TLR4 agonist therapy elicits antigen-specific T cell clonal expansion in metastatic leiomyosarcoma: a case series.

Frontiers in oncology·2026
Same author

How I treat soft tissue sarcomas.

Future oncology (London, England)·2026
Same author

Pre-diagnostic route reported by patients with sarcoma from the Netherlands, the UK, Australia and New Zealand: early detection challenges for general practitioners - an international observational cohort study.

BMJ open·2026
Same author

In DeFi-ance of "More Is Better": Questioning Long-Term Nirogacestat Use in Desmoid Tumors.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2026

Related Experiment Video

Updated: Aug 11, 2025

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma
09:17

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma

Published on: September 13, 2022

2.4K

Molecular profiling in desmoplastic small round cell tumours.

Yuen Bun Tam1, Robin L Jones2, Paul H Huang1

  • 1Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom.

The International Journal of Biochemistry & Cell Biology
|February 3, 2023
PubMed
Summary

Desmoplastic small round cell tumour (DSRCT) is a rare cancer with poor outcomes. Molecular profiling reveals new therapeutic targets and biomarkers for this aggressive soft tissue sarcoma.

Keywords:
BiomarkersDesmoplastic small round cell tumourDrug discoveryMolecular profilingSoft tissue sarcoma

More Related Videos

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

7.3K
Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
07:59

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer

Published on: September 8, 2023

1.2K

Related Experiment Videos

Last Updated: Aug 11, 2025

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma
09:17

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma

Published on: September 13, 2022

2.4K
Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

7.3K
Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
07:59

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer

Published on: September 8, 2023

1.2K

Area of Science:

  • Oncology
  • Genomics
  • Proteomics

Background:

  • Desmoplastic small round cell tumour (DSRCT) is an ultra-rare, aggressive soft tissue sarcoma with dismal patient outcomes.
  • Current multi-modal therapies offer limited efficacy, and targeted treatments are lacking for DSRCT.
  • Understanding the molecular landscape of DSRCT is crucial for developing effective therapeutic strategies.

Approach:

  • This review summarizes current molecular profiling studies in DSRCT, including next-generation sequencing and proteomics.
  • It highlights key genomic, epigenetic, and proteomic findings from DSRCT patient specimens and cell lines.
  • The review discusses the potential of these findings to identify novel and repurposed therapeutic candidates.

Key Points:

  • Comprehensive molecular profiling has significantly advanced our understanding of DSRCT biology.
  • Genomic, epigenetic, and proteomic data have identified several promising therapeutic targets.
  • Candidate therapies derived from molecular profiling are suitable for clinical trial translation.

Conclusions:

  • Molecular profiling is essential for advancing DSRCT research and improving patient outcomes.
  • Future integrated studies, such as proteogenomics, could further elucidate DSRCT biology.
  • Targeted therapies based on molecular insights hold promise for treating this rare cancer.