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Biological rhythms disruption mediates the association between mother's diagnosis of bipolar disorder and offspring's

Karen Jansen1, Mateus Grellert2, Adile Nexha3

  • 1Health and Behavior Department, Catholic University of Pelotas, Brazil; Cogniciência, Pelotas, RS, Brazil.

Journal of Affective Disorders
|February 3, 2023
PubMed

Insights

Mothers with Bipolar Disorder (BD) can impact their children

Area of Science:

  • Child Psychology
  • Neuroscience
  • Genetics

Background:

  • Maternal Bipolar Disorder (BD) is a significant concern for offspring mental health.
  • Understanding the pathways linking maternal BD to child emotional and behavioral problems (EBP) is crucial for early intervention.

Purpose of the Study:

  • To investigate if disruptions in children's biological rhythms mediate the association between maternal Bipolar Disorder (BD) and offspring emotional and behavioral problems (EBP).

Main Methods:

  • Assessed 492 children (ages 7-8) for biological rhythms disruption and EBP.
  • Mothers' mental health, including Bipolar Disorder (BD) diagnosis, was clinically evaluated.
  • Mediation analysis examined the role of offspring biological rhythms in the BD-EBP link.

Main Results:

  • Offspring of mothers with Bipolar Disorder (BD) exhibited more biological rhythms disruption and higher EBP prevalence.
  • Biological rhythms disruption accounted for 75% of the effect of maternal BD on offspring EBP.

Conclusions:

  • Disruption in children's biological rhythms fully mediates the impact of maternal Bipolar Disorder (BD) on their emotional and behavioral problems (EBP).
  • Findings support the development of interventions targeting biological rhythms in children of mothers with BD.
Abstract

Keywords:
Biological rhythmsBipolar disorderDevelopmental psychopathologyOffspring

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