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Diabetes mellitus: Lessons from COVID-19 for monkeypox infection
J A Ruiz-Pacheco1, L A Castillo-Díaz2, R Arreola-Torres3
1Investigador por México-CONACYT, Centro de Investigaciones Biomédicas de Occidente, IMSS, Guadalajara, Jalisco, México.
Primary Care Diabetes
|February 3, 2023
Summary
Type 2 diabetes mellitus impairs antiviral defenses, potentially increasing monkeypox severity. Antidiabetic drugs may improve immune responses against viral infections like monkeypox.
Area of Science:
- Immunology
- Virology
- Endocrinology
Background:
- Type 2 Diabetes Mellitus (T2DM) is linked to compromised antiviral defenses.
- The impact of T2DM on monkeypox severity is not well understood.
Purpose of the Study:
- To review immunological mechanisms linking T2DM and antiviral responses.
- To explore the potential impact of T2DM on monkeypox susceptibility and severity.
Main Methods:
- Literature search of PubMed and Google Scholar (1985-2022).
- Inclusion of all English-language articles.
Main Results:
- No studies currently exist on monkeypox in diabetic populations.
- High diabetes prevalence in regions with reported monkeypox cases.
Conclusions:
- Cessation of smallpox vaccination and high diabetes rates increase vulnerability to monkeypox.
- Preventing infection and using hypoglycemic agents that enhance antiviral immunity are key strategies.
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