Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Randomized Experiments

Randomized Experiments

The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Loss of systemic anti-viral immunity and LMP1-driven suppressive myeloid tumour niches converge to shape the immunobiology of Epstein-Barr virus-positive diffuse large B-cell lymphoma.

Leukemia·2026

Same author

Study on the safety evaluation of latent tuberculosis treatment in high‑risk groups for tuberculosis development: Study protocol for a multi‑center prospective observational cohort study in Korea (STEP-TB).

PloS one·2026

Same author

Beyond the Usual Suspects: Emerging Associations Between Epstein-Barr Virus Infection/Infectious Mononucleosis and Cancers.

Reviews in medical virology·2026

Same author

Manualised package intervention to achieve treatment adherence in people with tuberculosis: the IMPACT pilot cluster-RCT.

Health technology assessment (Winchester, England)·2026

Same author

Development of a clinical algorithm-based scoring system to diagnose smear-negative pulmonary tuberculosis in Sabah, Malaysia using the modified Delphi method.

Journal of global health·2026

Same author

Assessing T-cell responses to Epstein-Barr virus in individuals at risk for nasopharyngeal carcinoma.

Infectious agents and cancer·2026

Same journal

Complications of varicella and associated factors among hospitalized patients at a tertiary infectious disease hospital in Southern Vietnam.

BMC infectious diseases·2026

Same journal

Efficacy and safety of tenofovir alafenamide versus tenofovir disoproxil in chronic hepatitis b: a systematic review and meta-analysis of randomized controlled trials.

BMC infectious diseases·2026

Same journal

Preterm birth and the risk of respiratory syncytial virus hospitalisation in Australia's Northern Territory: a population-based cohort study.

BMC infectious diseases·2026

Same journal

Letter to the editor regarding 'clinical characteristics and factors associated with in-hospital post-surgical mortality in COVID-19 patients at a tertiary care center in Karachi, Pakistan.

BMC infectious diseases·2026

Same journal

Correction: Time to viral load suppression after enhanced adherence counseling among HIV patients attending antiretroviral therapy in Southwest Ethiopia.

BMC infectious diseases·2026

Same journal

Bacterial pathogens and antimicrobial resistance patterns in infections associated with stillbirths and under-five deaths in Ethiopia: a post-mortem surveillance study.

BMC infectious diseases·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Aug 11, 2025

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Published on: September 28, 2022

Mendelian randomisation identifies priority groups for prophylactic EBV vaccination.

Marisa D Muckian¹, James F Wilson^2,3, Graham S Taylor⁴

¹Old Medical School, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, UK. m.muckian@sms.ed.ac.uk.

BMC Infectious Diseases

|February 4, 2023

Summary

This summary is machine-generated.

Understanding Epstein Barr virus (EBV) infection risk is key for vaccine development. Causal risk factors identified include less education, more sexual partners, and earlier smoking initiation.

Keywords:

Epidemiology Epstein–Barr virus Mendelian randomization Public health Vaccination

More Related Videos

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

Related Experiment Videos

Last Updated: Aug 11, 2025

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Published on: September 28, 2022

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

Area of Science:

Infectious Disease Epidemiology
Genetic Epidemiology
Public Health

Background:

Epstein Barr virus (EBV) infects approximately 95% of the global population.
EBV is associated with serious health conditions like lymphomas and multiple sclerosis.
Understanding EBV infection risk factors is crucial for developing effective vaccines.

Purpose of the Study:

To identify causal risk factors for Epstein Barr virus (EBV) acquisition using Mendelian randomization (MR).
To overcome confounding and reverse causality issues present in observational studies of EBV infection.

Main Methods:

Literature review to create a causal diagram of EBV risk factors.
Genome-Wide Association Study (GWAS) on EBV serostatus in UK Biobank participants.
Two-sample MR analysis to determine causal risk factors for EBV serostatus.

Main Results:

Two novel loci associated with EBV serostatus were identified via GWAS.
Mendelian randomization confirmed shorter education duration, increased sexual partners, and earlier smoking initiation as causal risk factors for EBV serostatus.

Conclusions:

Identified causal risk factors can inform EBV vaccine development and deployment strategies.
Understanding who is most likely to acquire EBV aids in determining optimal vaccination age and priority groups.