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Polymerization-Induced Self-Assembly: An Emerging Tool for Generating Polymer-Based Biohybrid Nanostructures.

Liang Qiu1,2, Xinyue Han2, Chengfen Xing1

  • 1Key Laboratory of Hebei Province for Molecular Biophysics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin, 300401, P. R. China.

Small (Weinheim an Der Bergstrasse, Germany)
|February 4, 2023
PubMed
Summary

This review explores polymer-based biohybrid nanostructures (PBBNs) using polymerization-induced self-assembly (PISA). PISA offers an efficient method for creating advanced biomaterial composites for medicine and catalysis.

Keywords:
biomolecule-loaded polymeric nanostructuresbiomolecule-polymer conjugatesencapsulationgrafting-from/grafting-through methodpolymer-based biohybrid nanostructurespolymerization-induced self-assembly

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Area of Science:

  • Materials Science
  • Biotechnology
  • Polymer Chemistry

Background:

  • Combining biomolecules with synthetic polymers leverages nature's and synthetic chemistry's strengths.
  • This synergy is crucial for developing innovative materials for medicine, catalysis, and water treatment.
  • Advances in polymer synthesis and biomolecule understanding enable sophisticated polymer-based biohybrid nanostructures (PBBNs).

Purpose of the Study:

  • To review current preparation strategies for PBBNs using polymerization-induced self-assembly (PISA).
  • To highlight PISA as an efficient and versatile technique for fabricating PBBNs.
  • To discuss the advantages, drawbacks, and commercialization obstacles of PISA-based PBBN fabrication.

Main Methods:

  • Grafting-from and grafting-through polymerization strategies.
  • Encapsulation of biomolecules during and after the PISA process.
  • Review of existing literature on PISA for PBBN synthesis.

Main Results:

  • PISA is demonstrated as an effective technique for producing various PBBNs.
  • Different PISA-based strategies, including grafting and encapsulation, are illustrated.
  • The review synthesizes current approaches to PBBN fabrication via PISA.

Conclusions:

  • PISA offers significant advantages for creating PBBNs.
  • Further research is needed to overcome obstacles for commercial applications.
  • PBBNs fabricated via PISA hold promise for diverse applications.