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Updated: Aug 11, 2025

Dosimetry for Cell Irradiation using Orthovoltage 40-300 kV X-Ray Facilities
Published on: February 20, 2021
Technical note: TERMA scaling as an effective heterogeneity correction model for convolution-based external-beam
Linda Laakkonen1,2, Zheyong Fan1, Ari Harju1
1Varian Medical Systems, a Siemens Healthineers Company, Helsinki, Finland.
Background:
In highly heterogeneous medium, such as one with lung tissue or air cavities, the dose in the low-density region or after it, as calculated by the conventional methods based on convolution with an energy-spreading kernel, is usually overestimated in comparison with measurements or more accurate predictions.
Purpose:
To correct the overestimation, we propose a method of scaling the total energy released per mass (TERMA).
Methods:
The scaling depends on both the density distribution and the effective beam size in the lateral direction.
Results:
The corrected convolution method achieved a significantly improved accuracy in both the lung-like tissue and the water-like region after air, compared to the uncorrected method. The TERMA correction only adds about 10% to the overall computational cost.
Conclusions:
Due to the improvement in accuracy and the preservation of computational efficiency, the proposed dose calculation method will be valuable for inverse treatment planning.
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