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Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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Related Experiment Video

Updated: Aug 11, 2025

Author Spotlight: EasyFlow - An Economical and Adaptable Perfusion Bioreactor for Large Blood Vessel Culture
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Vascular ageing: moving from bench towards bedside.

Rachel E Climie1,2,3, Jordi Alastruey4, Christopher C Mayer5

  • 1Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool St, 7000 Hobart, Australia.

European Journal of Preventive Cardiology
|February 4, 2023
PubMed
Summary
This summary is machine-generated.

Vascular ageing (VA) reflects cumulative cardiovascular risk factor effects on arteries. Understanding and measuring VA can help identify individuals at high risk early, aiding cardiovascular disease prevention.

Keywords:
AgeingCardiovascular disease preventionVascular damage

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Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology
  • Public Health

Background:

  • Cardiovascular disease (CVD) prevention is a major public health concern.
  • Early identification of individuals with sub-clinical cardiovascular risk is crucial for disease management.
  • Vascular ageing (VA) represents progressive deterioration of vascular structure and function, linked to CVD.

Purpose of the Study:

  • To address key questions surrounding vascular ageing (VA).
  • To enhance clinical understanding and application of VA assessment.
  • To bridge the gap between VA research and routine clinical practice.

Main Methods:

  • This is a state-of-the-art review.
  • Expert network of scientists, clinicians, engineers, and industry partners.
  • Focused on addressing six critical questions regarding VA.

Main Results:

  • Vascular ageing (VA) integrates the lifelong impact of cardiovascular risk factors on the arterial wall.
  • VA has the potential to identify individuals at elevated cardiovascular risk during early disease development.
  • Current clinical adoption of VA measurement is limited by lack of consensus and practical challenges.

Conclusions:

  • Standardizing the characterization of physiological versus pathological VA is necessary.
  • Routine clinical measurement of VA is not yet established but is a goal for improved CVD risk stratification.
  • Further research and consensus-building are needed to facilitate the clinical implementation of VA assessment.