Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Primary hyperparathyroidism in 23 cases].

S Morimoto1, T Yoshida, T Fukatani

  • 1Department of Urology, Wakayama Medical College.

Hinyokika Kiyo. Acta Urologica Japonica
|June 1, 1987
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism.

Nature·1997
Same author

Expression of p16INK4a suppresses the unbounded and anchorage-independent growth of a glioblastoma cell line that lacks p16INK4a.

Biochemical and biophysical research communications·1997
Same author

Interaction of PKN with alpha-actinin.

The Journal of biological chemistry·1997
Same author

Geranylgeranylated rho small GTPase(s) are essential for the degradation of p27Kip1 and facilitate the progression from G1 to S phase in growth-stimulated rat FRTL-5 cells.

The Journal of biological chemistry·1997
Same author

Consumption of cow milk and egg by lactating women and the presence of beta-lactoglobulin and ovalbumin in breast milk.

The American journal of clinical nutrition·1997
Same author

Effects of PACAP-VIP hybrid peptides on gastric blood flow in conscious dogs.

Annals of the New York Academy of Sciences·1996

Primary hyperparathyroidism is often caused by adenoma. Elevated serum calcium is the most sensitive diagnostic indicator, with imaging techniques aiding localization before surgery.

Area of Science:

  • Endocrinology
  • Surgical Pathology

Background:

  • Primary hyperparathyroidism (PHPT) is a condition characterized by excessive parathyroid hormone (PTH) production.
  • This retrospective study analyzes clinical and histopathological data from PHPT cases managed over a 17-year period.

Purpose of the Study:

  • To evaluate diagnostic laboratory tests for PHPT.
  • To assess the efficacy of non-invasive imaging modalities for parathyroid adenoma localization.
  • To examine the biochemical recovery following parathyroidectomy.

Main Methods:

  • Review of 23 primary hyperparathyroidism cases diagnosed between 1969 and 1985.
  • Analysis of histopathological findings (adenoma vs. hyperplasia).
  • Evaluation of serum calcium, ionized calcium, phosphorus, and PTH levels.

Related Experiment Videos

  • Assessment of Tl-chloride scintigraphy and computed tomography for preoperative localization.

    • Main Results:

    • Histopathology revealed adenoma in 22 cases and hyperplasia in 1 case.
    • Elevated serum calcium was the most sensitive diagnostic marker (91% sensitivity).
    • Tl-chloride scintigraphy and CT correctly localized parathyroid adenomas in 80% and 67% of cases, respectively.
    • Post-parathyroidectomy, serum calcium normalized within 12 hours, while phosphorus normalized over approximately 1 week.

    Conclusions:

    • Serum calcium is a highly sensitive indicator for diagnosing primary hyperparathyroidism.
    • Non-invasive imaging like Tl-chloride scintigraphy and CT are valuable for preoperative localization of parathyroid adenomas.
    • Surgical intervention leads to rapid biochemical correction of calcium and phosphorus imbalances.