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Sonic Hedgehog Signaling Pathway: A Role in Pain Processing

Guangda Zheng1, Juanxia Ren2, Lu Shang2

  • 1Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beixiange 5, Xicheng District, Beijing, 100053, China.

Neurochemical Research
|February 4, 2023
PubMed

Insights

New research highlights the Sonic hedgehog (Shh) signaling pathway

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Pain Research

Background:

  • Pain is a complex symptom with unsatisfactory existing treatments.
  • New therapeutic targets for pain management are urgently needed.
  • The Sonic hedgehog (Shh) signaling pathway plays a role in development and nervous system regulation.

Purpose of the Study:

  • To review recent studies on the Shh signaling pathway in pain.
  • To explore the role of Shh signaling in various pain conditions.
  • To identify potential therapeutic targets within the Shh pathway for pain management.

Main Methods:

  • Literature review of recent studies on the Shh signaling pathway.
  • Analysis of Shh pathway involvement in different pain models and diseases.
  • Synthesis of findings regarding Shh dysregulation in pain states.

Main Results:

  • The Shh signaling pathway is dysregulated in multiple pain conditions.
  • Examples include pancreatic cancer pain, bone cancer pain, and degenerative disc disease.
  • Shh pathway alterations are observed in chronic post-thoracotomy pain and toothache.

Conclusions:

  • The Shh signaling pathway is implicated in diverse pain pathologies.
  • Dysregulation of Shh signaling presents a potential therapeutic avenue.
  • Further investigation into the Shh pathway may yield novel pain management strategies.
Keywords:
Cancer painChronic post-thoracotomy painNeuropathic painPain processingSonic hedgehog signaling pathway

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