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Updated: Aug 11, 2025

Investigation of Spatial Interaction Between Astrocytes and Neurons in Cleared Brains
Published on: March 31, 2022
The Memory Orchestra: Contribution of Astrocytes
Yi-Hua Chen1, Shi-Yang Jin2, Jian-Ming Yang2
1State Key Laboratory of Organ Failure Research, Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong Province Key Laboratory of Psychiatric Disorders, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China. chenyihua@smu.edu.cn.
Abstract:
For decades, memory research has centered on the role of neurons, which do not function in isolation. However, astrocytes play important roles in regulating neuronal recruitment and function at the local and network levels, forming the basis for information processing as well as memory formation and storage. In this review, we discuss the role of astrocytes in memory functions and their cellular underpinnings at multiple time points. We summarize important breakthroughs and controversies in the field as well as potential avenues to further illuminate the role of astrocytes in memory processes.
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