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The many faces of hypertension in individuals with type 1 diabetes
Raija Lithovius1, Per-Henrik Groop2,
1Folkhälsan Institute of Genetics, Folkhälsan Research Centre, Helsinki, Finland; Department of Nephrology, University of Helsinki and Helsinki University Hospital, Finland; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Finland.
Insights
Type 1 diabetes patients often have abnormal blood pressure (BP) patterns, including white-coat and masked hypertension. Early detection of these BP variations is crucial for preventing cardiovascular and renal complications.
Area of Science:
- Cardiology
- Endocrinology
- Nephrology
Background:
- Type 1 diabetes is associated with various abnormal blood pressure (BP) patterns.
- These include discrepancies between office and out-of-office BP measurements (white-coat and masked hypertension), disturbed circadian BP variability (abnormal dipping, nocturnal hypertension), and treatment-resistant hypertension.
Conclusions:
- Disturbed BP patterns are prevalent and significant in type 1 diabetes.
- Comprehensive BP monitoring is necessary for accurate assessment.
- Further research is needed to optimize management and improve prognosis.
Abstract:
Several disturbed blood pressure (BP) patterns, including disparities between office and out-of-office BP measurements (such as white-coat and masked hypertension), disturbed circadian BP variability (such as abnormal dipping patterns and nocturnal hypertension) and treatment-resistant hypertension, are common in individuals with type 1 diabetes. Consequently, office or home BP measurements alone may not reflect real BP variation and may lead to inadequate diagnosis and treatment of hypertension. The early detection of these disturbed BP patterns is especially crucial in individuals with type 1 diabetes, as these patterns may indicate future development of adverse cardiovascular and renal outcomes. In this review we will describe these disturbed BP patterns and discuss recent findings on their prevalence and outcomes. We will also address critical areas for future research to determine the true prevalence and prognosis of disturbed BP patterns, and to optimize and improve the knowledge and management of high-risk individuals with type 1 diabetes and disturbed BP patterns.
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