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Updated: Aug 11, 2025

Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells
Published on: August 17, 2022
Systemic lupus erythematosus myocarditis after COVID-19 vaccination
Miguel Sogbe1, Andrés Blanco-Di Matteo1, I Madeleine Di Frisco2
1Internal Medicine Department, Clínica Universidad de Navarra, Pamplona, Spain.
Introduction:
Cases of acute myocarditis have been after administration of the BNT162b2 and Ad26.COV2.S vaccine.
Objective:
Describe another possible mechanism of myocarditis after COVID-19 vaccination.
Case Presentation:
We describe the clinical case of a 72-year-old female with pleuritic chest pain one week after the third of the BNT162b2 mRNA vaccine. Serological tests for cardiotropic pathogens were negative, and autoimmunity screening was positive with anti-nuclear antibody (ANA) in 1:160 dilution, Anti-double-stranded DNA (anti-dsDNA), and anti-histone antibodies. 18F-fluoro-deoxy-glucose (FDG) positron emission tomography/computed tomography (PET/CT) showed a focal myocardial and pericardial inflammatory process in the cardiac apex.
Results And Discussion:
Systemic lupus erythematosus (SLE) diagnosis was made with myocardial affection. As far as we know, this is the first report of a case of lupus myocarditis after the COVID-19 vaccine.
Conclusion:
Given the pathogenic rationales, the association between SLE and myocarditis should be considered.
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