Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Schmidt-Lanterman clefts: a morphometric study in human sural nerve.

F Buchthal1, F Carlsen, F Behse

  • 1National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD.

The American Journal of Anatomy
|October 1, 1987
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Understanding geographic origins and history of admixture among chimpanzees in European zoos, with implications for future breeding programmes.

Heredity·2013
Same author

Application of adenosine triphosphate and related compounds to the spinal cord of the cat.

The Journal of physiology·2010
Same author

On the effect of adenosine triphosphate on myosin threads.

Acta physiologica Scandinavica·2010
Same author

Muscle.

Annual review of physiology·2010
Same author

Action potentials in pathological postural reflex activity (spasticity and rigidity).

Acta psychiatrica et neurologica·2010
Same author

Local public services and migration: educational change evidence from Norwegian municipalities.

The Review of regional studies·2002

Schmidt-Lanterman (SL) clefts in human sural nerve fibers show a linear relationship with myelin thickness. Their extent and impact on axon diameter vary significantly between large and small myelinated fibers.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Histology

Background:

  • Schmidt-Lanterman (SL) clefts are specialized regions within the myelin sheath of nerve fibers.
  • Understanding the structural characteristics of SL clefts is crucial for comprehending nerve fiber physiology and pathology.

Purpose of the Study:

  • To quantify the incidence, extent, and morphological impact of SL clefts in large and small myelinated fibers of the human sural nerve.
  • To investigate the relationship between SL clefts and myelin thickness.

Main Methods:

  • Morphometric analysis of myelinated fibers in the human sural nerve.
  • Quantification of Schmidt-Lanterman clefts per unit length.
  • Measurement of SL cleft extent and its relation to internodal length.
  • Analysis of fiber and axon diameter changes within SL and nodal regions.

Related Experiment Videos

Main Results:

  • Large myelinated fibers exhibited 35 SL clefts/mm, while small fibers had 8 SL clefts/mm.
  • SL cleft incidence correlated linearly with myelin thickness.
  • SL clefts occupied ~50% of internodal length in large fibers and 6% in small fibers.
  • Axon diameter was reduced by 17% (large) and 28% (small) fibers within SL regions.
  • Axon diameter reduction of 40-50% was observed in the nodal region.

Conclusions:

  • The density and extent of SL clefts are significantly different between large and small myelinated fibers.
  • SL clefts represent substantial regions that influence axon caliber, particularly in smaller fibers.
  • Nodal regions also show significant axon diameter reduction, highlighting regional specializations within nerve fibers.